Topic description and stories

Beta-Amyloid Plaques and Tau in the Brain

Following the hops of disordered proteins could lead to future treatments of Alzheimer’s disease

14 Jan 2021

Study shows how to determine the elusive motions of proteins that remain disordered.

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Inducing lysosome motion with light leads to a rapid and significant extension of ER network.

Driving force behind cellular ‘protein factories’ could have implications for neurodegenerative disease

16 Dec 2020

Researchers have identified the driving force behind a cellular process linked to neurodegenerative disorders such as Parkinson’s and motor neurone...

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Conceptual image showing blurred brain with loss of neuronal networks

Scientists reveal plan to target the cause of Alzheimer’s disease

24 Sep 2018

Researchers have developed a new way to target the toxic particles that destroy healthy brain cells in Alzheimer’s disease.

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New research facility for neurodegenerative disorders opened in Cambridge

21 Sep 2018

The Chemistry of Health building, a new facility dedicated to the use of chemical techniques to combat disease, in particular neurodegenerative...

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Brain cholesterol associated with increased risk of Alzheimer’s disease

07 May 2018

Researchers have shown how cholesterol – a molecule normally linked with cardiovascular diseases – may also play an important role in the onset and...

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Tyrosine hydroxylase positive neuron stained with a synaptic marker

Calcium may play a role in the development of Parkinson’s disease

19 Feb 2018

Researchers have found that excess levels of calcium in brain cells may lead to the formation of toxic clusters that are the hallmark of Parkinson’s...

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Brain showing hallmarks of Alzheimer’s disease (plaques in blue)

Computer-designed antibodies target toxins associated with Alzheimer’s disease

22 Jun 2017

Researchers at the University of Cambridge have designed antibodies that target the protein deposits in the brain associated with Alzheimer’s disease...

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Brain showing hallmarks of Alzheimer's disease (plaques in blue)

New imaging technique measures toxicity of proteins associated with Alzheimer’s and Parkinson’s diseases

23 Nov 2016

A new super-resolution imaging technique allows researchers to track how surface changes in proteins are related to neurodegenerative diseases such...

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Parkinson’s Disease protein plays vital “marshalling” role in healthy brains

19 Sep 2016

Researchers have identified how alpha-synuclein, the protein associated with Parkinson’s Disease, enables communication between neurons in the brain...

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In healthy tissues, a gene expression signature associated with amyloid-beta and tau aggregation echoes the progression of AD well before the onset of the disease.

Gene signature in healthy brains pinpoints the origins of Alzheimer’s disease

10 Aug 2016

A specific gene expression pattern maps out which parts of the brain are most vulnerable to Alzheimer’s disease, decades before symptoms appear, and...

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Researchers identify when Parkinson’s proteins become toxic to brain cells

14 Mar 2016

Observation of the point at which proteins associated with Parkinson’s disease become toxic to brain cells could help identify how and why people...

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Fibrils of amyloid-beta

Researchers identify ‘neurostatin’ that may reduce the risk of Alzheimer’s disease

12 Feb 2016

An approved anti-cancer drug successfully targets the first step in the toxic chain reaction that leads to Alzheimer’s disease, suggesting that...

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