Evidence has been building in recent years that our diet, our habits or traumatic experiences can have consequences for the health of our children – and even our grandchildren. The explanation that has gained most currency for how this occurs is so-called ‘epigenetic inheritance’ – patterns of chemical ‘marks’ on or around our DNA that are hypothesised to be passed down the generations. But new research from the University of Cambridge suggests that this mechanism of non-genetic inheritance is likely to be very rare.
Protein discovery may explain why some patients develop resistance to new class of anti-cancer drugs25 Jul 2018
A team of researchers at the University of Cambridge has identified a protein complex that might explain why some cancer patients treated with the revolutionary new anti-cancer drugs known as PARP inhibitors develop resistance to their medication.
The past few years has seen an explosion in the number of studies using organoids – so-called ‘mini organs’. While they can help scientists understand human biology and disease, some in the field have questioned their usefulness. But as the field matures, we could see their increasing use in personalised and regenerative medicine.
Scientists have created mini biological models of human primary liver cancers, known as organoids, in the lab for the first time. In a paper published in Nature Medicine, the tiny laboratory models of tumours were used to identify a new drug that could potentially treat certain types of liver cancer.
In the centenary year of the publication of a seminal treatise on the physical and mathematical principles underpinning nature – On Growth and Form by D’Arcy Wentworth Thompson – a Cambridge physicist has led a study describing an elegantly simple solution to a puzzle that has taxed biologists for centuries: how complex branching patterns of tissues arise.
Tony Kouzarides is passionate about ecosystems: well-balanced communities that flourish on mutual and dynamic interactions. But the ecosystems that excite him are not made up of plants, animals and environments. They’re made up of experts.
Scientists have shown how the precursors of egg and sperm cells – the cells that are key to the preservation of a species – arise in the early embryo by studying pig embryos alongside human stem cells.
Two Cambridge institutes have today been confirmed as major research centres by biomedical research charity Wellcome, receiving continued support for a further five years. The centres will be co-funded by Cancer Research UK (CRUK) and the Medical Research Council (MRC) respectively.
Cambridge spin-out Carrick Therapeutics raises $95 million in funding, representing the largest-ever early stage investment in a UK university spin-out company.