Topic description and stories

Illustration of DNA molecules

DNA sequencing method lifts ‘veil’ from genome black box

23 Jan 2023

Many life-saving drugs directly interact with DNA to treat diseases such as cancer, but scientists have struggled to detect how and why they work –...

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Merkel Cell Carcinoma

Largest study of whole genome sequencing data reveals new clues to causes of cancer

21 Apr 2022

DNA analysis of thousands of tumours from NHS patients has found a ‘treasure trove’ of clues about the causes of cancer, with genetic mutations...

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DNA Double Helix

Genomes front and centre of rare disease diagnosis

24 Jun 2020

Cambridge-led study discovers new genetic causes of rare diseases, potentially leading to improved diagnosis and better patient care.

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Close-up of virus molecule

Identification of viruses and bacteria could be sped up through computational methods

30 Mar 2020

A new multinational study has shown how the process of distinguishing viruses and bacteria could be accelerated through the use of computational...

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Genome editing reveals role of gene important for human embryo development

20 Sep 2017

Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development. This is the...

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Snip, snip, cure: correcting defects in the genetic blueprint

14 Jul 2017

Gene editing using ‘molecular scissors’ that snip out and replace faulty DNA could provide an almost unimaginable future for some patients: a...

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Usermontu Mummy

First complete genome data extracted from ancient Egyptian mummies

30 May 2017

Study finds that ancient Egyptians were most closely related to ancient populations from the Middle East and Western Asia.

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Human Genome mannequin

Algorithm matches genetic variation to disease symptoms and could improve diagnosis of rare diseases

19 Apr 2017

A faster and more accurate method of identifying which of an individual’s genes are associated with particular symptoms has been developed by a team...

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Visualising the genome: researchers create first 3D structures of active DNA

13 Mar 2017

Scientists have determined the first 3D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes...

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Crystal structure of parallel quadruplexes from human telomeric DNA.

Quadruple helix form of DNA may aid in the development of targeted cancer therapies

12 Sep 2016

Researchers have identified the role that a four-stranded version of DNA may play in the role of cancer progression, and suggest that it may be used...

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abstract blood cells

Anatomy of a decision: mapping early development

06 Jul 2016

In the first genome-scale experiment of its kind, researchers have gained new insights into how a mouse embryo first begins to transform from a ball...

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DNA representation

Expanding the DNA alphabet: ‘extra’ DNA base found to be stable in mammals

22 Jun 2015

A rare DNA base, previously thought to be a temporary modification, has been shown to be stable in mammalian DNA, suggesting that it plays a key role...

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