Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

29 Nov 2016

Researchers from the Wellcome Trust Sanger Institute and the University of Cambridge have created sOPTiKO, a more efficient and enhanced inducible CRISPR genome editing platform. Today, in the journal Development, they describe how the freely available single-step system works in every cell in the body and at every stage of development. This new approach will aid researchers in developmental biology, tissue regeneration and cancer.

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Dish Life: a Cambridge Shorts film

21 Nov 2016

Science is demanding as well as exciting. Dish Life, the final of four Cambridge Shorts films, compares the task of raising stem cells in the lab to the challenge of looking after a gang of unruly kids. In conversation with real-life children, scientists show how tricky it is to work with these ‘super cells’.

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Anatomy of a decision: mapping early development

06 Jul 2016

In the first genome-scale experiment of its kind, researchers have gained new insights into how a mouse embryo first begins to transform from a ball of unfocussed cells into a small, structured entity. Published in Nature, the single-cell genomics study was led by the European Bioinformatics Institute (EMBL-EBI) and the University of Cambridge.

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Scientists develop human embryos beyond implantation stage for first time

04 May 2016

A new technique that allows embryos to develop in vitro beyond the implantation stage (when the embryo would normally implant into the womb) has been developed by scientists at the University of Cambridge allowing them to analyse for the first time key stages of human embryo development up to 13 days after fertilisation. The technique could open up new avenues of research aimed at helping improve the chances of success of IVF.

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Embryo development: Some cells are more equal than others even at four-cell stage

24 Mar 2016

Genetic ‘signatures’ of early-stage embryos confirm that our development begins to take shape as early as the second day after conception, when we are a mere four cells in size, according to new research led by the University of Cambridge and EMBL-EBI. Although they seem to be identical, the cells of the two day-old embryo are already beginning to display subtle differences.

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