Topic description and stories

Arthur Hatt at a festival

Lab-grown ‘mini-guts’ could change how we treat Crohn’s disease

11 Jun 2024

Cambridge scientists have grown ‘mini-guts’ in the lab to help understand Crohn’s disease, showing that ‘switches’ that modify DNA in gut cells play...

Read more
Artist's impression of Crohn's disease

Treating newly-diagnosed Crohn's patients with advanced therapy leads to dramatic improvements in outcomes

22 Feb 2024

A large-scale clinical trial of treatment strategies for Crohn’s disease has shown that offering early advanced therapy to all patients straight...

Read more
Emerging intestinal villi with stem cells (green) supporting their growth

Gut research identifies key cellular changes associated with childhood-onset Crohn’s Disease

07 Dec 2020

Scientists have tracked the very early stages of human foetal gut development in incredible detail, and found specific cell functions that appear to...

Read more

Dr James Lee

New prognostic test could enable personalised treatment of inflammatory bowel disease

03 May 2019

Scientists at the University of Cambridge have developed a new test that can reliably predict the future course of inflammatory bowel disease in...

Read more
DNA

Crohn’s disease risk and prognosis determined by different genes, study finds

09 Jan 2017

Researchers have identified a series of genetic variants that affect the severity of Crohn’s disease, an inflammatory bowel disease – but...

Read more
Histopathological image of the active stage of ulcerative colitis. Endoscopic biopsy. Hematoxylin & eosin stain.

Scientists explore using stem cells to treat inflammatory bowel disease

18 Oct 2013

Research paves way for new therapies for ulcerative colitis and Crohn's disease

Read more

Gene variant linked to prognosis in inflammatory diseases

04 Oct 2013

Researchers have identified a gene that is linked to long term disease outcome in Crohn's disease, a common inflammatory bowel disorder, and...

Read more

Specialised intestinal cells cause some cases of Crohn’s disease

02 Oct 2013

Researchers discover that the cells play a major role in inflammation which underlies Crohn’s disease in small intestine.

Read more