Only a small proportion of cases of dementia are thought to be inherited – the cause of the vast majority is unknown. Now, in a study published today in the journal Nature Communications, a team of scientists led by researchers at the University of Cambridge believe they may have found an explanation: spontaneous errors in our DNA that arise as cells divide and replicate.
An international team of researchers led by scientists at the University of Cambridge and MSD has created the first detailed genetic map of human proteins, the key building blocks of biology. These discoveries promise to enhance our understanding of a wide range of diseases and aid development of new drugs.
A thousand-year-old tooth has provided genetic evidence that the so-called “Taíno”, the first indigenous Americans to feel the full impact of European colonisation after Columbus arrived in the New World, still have living descendants in the Caribbean today.
A genetic trawl through the DNA of almost 100,000 people, including 17,000 patients with the most common type of ovarian cancer, has identified 12 new genetic variants that increase risk of developing the disease and confirmed the association of 18 of the previously published variants.
Ancient DNA analyses show that – unlike elsewhere in Europe – farmers from the Near East did not overtake hunter-gatherer populations in the Baltic. The findings also suggest that the Balto-Slavic branch of the Indo-European language family originated in the Steppe grasslands of the East.
Researchers have identified a series of genetic variants that affect the severity of Crohn’s disease, an inflammatory bowel disease – but surprisingly, none of these variants appear to be related to an individual’s risk of developing the condition in the first place.
DNA sequencing has defined a new genetic disorder that affects movement, enabling patients with dystonia — a disabling condition that affects voluntary movement — to be targeted for treatment that brings remarkable improvements, including restoring independent walking.