‘Clogged-up’ immune cells help explain smoking risk for TB

24 Mar 2016

Smoking increases an individual’s risk of developing tuberculosis (TB) – and makes the infection worse – because it causes vital immune cells to become clogged up, slowing their movement and impeding their ability to fight infection, according to new research published in the journal Cell.

Read More

A whole host of options

09 Oct 2015

Almost one in four of the world’s cases of tuberculosis (TB) are in India and the disease is constantly adapting itself to outwit our medicines. Could the answer lie in targeting not the bacteria but its host, the patient?

Read More
Mycobacterium tuberculosis

Gene discovery provides clues to how TB may evade the immune system

16 Mar 2015

The largest genetic study of tuberculosis (TB) susceptibility to date has led to a potentially important new insight into how the pathogen manages to evade the immune system. Published today in the journal Nature Genetics, the study advances understanding of the biological mechanisms involved in TB, which may open up new avenues to design efficient vaccines for its prevention.

Read More
Small chemical fragments

Small is beautiful in drug discovery

01 May 2010

Cambridge scientists are employing fragment-based drug discovery approaches - a technique that involves "growing" potent drugs from tiny chemical fragments - to tackle tuberculosis and cancer.

Read More