Eating a high fat and high sugar diet when pregnant leads to metabolic impairments in both the mother and her unborn child, which may 'program' them for potential health complications later in life, a study in mice has shown.
OCD can be a devastating condition: therapy and medication often doesn’t work, leaving many people unable to hold down a job or a relationship – or even to leave their house. In our series of films, science writer David Adam looks at how research at Cambridge using animals helps us understand what is happening in the brain – and may lead to better treatments.
Infections during pregnancy may interfere with key genes associated with autism and prenatal brain development21 Mar 2017
If a mother picks up an infection during pregnancy, her immune system will kick into action to clear the infection – but this self-defence mechanism may also have a small influence how her child’s brain develops in the womb, in ways that are similar to how the brain develops in autism spectrum disorders. Now, an international team of researchers has shown why this may be the case, in a study using rodents to model infection during pregnancy.
Scientists have determined the first 3D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately folds to fit together inside the cell nuclei.
Cambridge scientist shares world’s largest neuroscience prize for research on the brain’s reward system06 Mar 2017
A Cambridge neuroscientist has today won the world’s most valuable prize for brain research, shared with two London neuroscientists. This year, The Brain Prize for 2017 is awarded to Cambridge’s Wolfram Schultz, together with Peter Dayan and Ray Dolan from University College London for their analysis of how the brain recognises and processes reward.
Scientists at the University of Cambridge have managed to create a structure resembling a mouse embryo in culture, using two types of stem cells – the body’s ‘master cells’ – and a 3D scaffold on which they can grow.
Early warning signs of Huntington’s disease have been uncovered in a sheep carrying the human disease-causing genetic variant, providing new insights into this devastating illness, a new study in Scientific Reports has found.
A large-scale genetic study has provided strong evidence that the development of insulin resistance – a risk factor for type 2 diabetes and heart attacks and one of the key adverse consequences of obesity – results from the failure to safely store excess fat in the body.
A weight loss condition that affects patients with cancer has provided clues as to why cancer immunotherapy – a new approach to treating cancer by boosting a patient’s immune system – may fail in a substantial number of patients.