It is almost impossible for an injured heart to fully mend itself. Within minutes of being deprived of oxygen – as happens during a heart attack when arteries to the heart are blocked – the heart’s muscle cells start to die. Sanjay Sinha wants to mend these hearts so that they work again.
Sherpas have evolved to become superhuman mountain climbers, extremely efficient at producing the energy to power their bodies even when oxygen is scarce, suggests new research published today in the Proceedings of National Academy of Sciences (PNAS).
A BLUEPRINT for blood cells: Cambridge researchers play leading role in major release of epigenetic studies17 Nov 2016
Cambridge researchers have played a leading role in several studies released today looking at how variation in and potentially heritable changes to our DNA, known as epigenetic modifications, affect blood and immune cells, and how this can lead to disease.
The process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of the genome, according to research published today. The discovery could shed light on why many human genetic studies have previously not been able to fully explain how certain diseases, such as type 2 diabetes and obesity, are inherited.
People who live or work near to a greater number of takeaway outlets are more likely to eat more takeaway food and to be overweight, but new research indicates that neighbourhoods that are saturated with fast food outlets may be particularly unhealthy for people who are socioeconomically disadvantaged.
Some people with high levels of ‘good’ high density lipoprotein cholesterol (HDL-C) are at increased risk of coronary heart disease, contrary to earlier evidence that people with more HDL-C are usually at lower heart disease risk. This finding comes from an international study involving researchers at the University of Cambridge, funded by the British Heart Foundation (BHF).
The process of ageing begins even before we are born, according to an international team of researchers led by the University of Cambridge. In a study using rats to model pregnancy and fetal development, the researchers also found that providing mothers with antioxidants during pregnancy meant that their offspring aged more slowly in adulthood.
Children should be given more support to enable them to be more active during the winter, particularly at weekends, say researchers from the University of Cambridge. Their call comes in response to their findings that children are less active and spend more time sitting in autumn and winter compared to other times of the year.
Cambridge researchers have found the strongest evidence to date that human pluripotent stem cells – cells that can give rise to all tissues of the body – will develop normally once transplanted into an embryo. The findings, published today in the journal Cell Stem Cell, could have important implications for regenerative medicine.
The fatter we are, the more our body appears to produce a protein that inhibits our ability to burn fat, suggests new research published in the journal Nature Communications. The findings may have implications for the treatment of obesity and other metabolic diseases.